Different organization of collagen fibrils in stress‐incontinent women of fertile age
作者： Gunvor Ekman-Ordeberg , Anders Malmström , Olle Johansson , Christian Falconer , Gunilla Westergren-Thorsson
DOI: 10.1034/J.1600-0412.1998.770119.X
关键词:
摘要: Objective. The objective was to test the hypothesis that stress urinary incontinence in women is correlated changes paraurethral connective tissue ultrastructure and metabolism.Methods. Transvaginal biopsies were obtained from of fertile age with matched continent controls. All stress-incontinent characterized urodynamic investigation. In biopsies, collagen concentration, measured as hydroxyproline, degree extraction by pepsin digestion quantified. Proteoglycan composition concentration analyzed using Alcian blue precipitation, followed electrophoretic separation quantification. Using Northern blots mRNA levels for collagens I III, small proteoglycans decorin biglycan, large proteoglycan versican, Collagen organization examined transmission electron microscopy diameters fibrils wi...
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