Anxiety After Cardiac Arrest/Cardiopulmonary Resuscitation Exacerbated by Stress and Prevented by Minocycline
作者： Gretchen N. Neigh , Kate Karelina , Erica R. Glasper , Stephanie L.K. Bowers , Ning Zhang
DOI: 10.1161/STROKEAHA.109.564146
关键词:
摘要: Background and Purpose— Stress is an important risk factor for cardiovascular disease; however, most of the research on this topic has focused incidence rather than outcome. The goal study was to determine effects prior exposure chronic stress ischemia-induced neuronal death, microglial activation, anxiety-like behavior. Methods— In Experiment 1, mice were exposed 3 weeks daily restraint (3 hours) then subjected either 8 minutes cardiac arrest/cardiopulmonary resuscitation (CA/CPR) or sham surgery. Anxiety-like behavior, damage assessed postischemic Day 4. 2, infused intracerebroventricularly with minocycline (10 μg/day) effect inhibiting post-CA/CPR activation development behavior death. Results— CA/CPR precipitated increased within hippocampus relative s...
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