Significance of NMDA receptor-related glutamatergic amino acid levels in peripheral blood of patients with schizophrenia

摘要: Hypo-function of N-methyl d-aspartate (NMDA) receptors is strongly involved in the brain pathophysiology schizophrenia. Several excitatory amino acids, such as endogenous glutamate, glycine, serine and alanine, which are glutamate neurotransmission via NMDA receptors, were studied to further understand schizophrenia find a biological marker for this disease, particularly peripheral blood. In literature review, we connect several earlier clinical studies acid levels blood historical context. Finally, join these results our previous studies, Juntendo University Schizophrenia Projects (JUSP), investigated plasma glutamatergic detail, considered whether may be diagnostic, therapeutic, or symptomatic markers. This review concludes that glycine alanine could schizophrenia, while exogenous augmentation therapies therapeutic Noteworthy d-serine reflect its levels, prove useful diagnostic addition, measurements new molecules, glutathione, promising. future with agents still being examined animal lay foundation development next-generation antipsychotics.