Female Mice Have Higher Angiogenesis in Perigonadal Adipose Tissue Than Males in Response to High-Fat Diet.

摘要: Background: Impaired capillary growth (angiogenesis) in skeletal muscle and adipose tissue contributes to the development of metabolic disorders obese males. This association remains unexplored females, despite mounting evidence that endothelial cells have sex-specific transcriptional profiles. Therefore, herein we assessed whether males females show distinct angiogenic capacities response diet-induced obesity. Methods: Age-matched male female mice were fed normal chow or high-fat obesogenic diets for 16 weeks. At end diet period, systemic glucose disposal was as well insulin sensitivity visceral tissue. Capillary content expression regulators also evaluated these tissues. Results: When placed on a diet, gained less weight than showed phenotype similar NC-fed mice, contrasting with impaired whole-body metabolism observed high-fat-fed However, high-fat-feeding elevated serum lipid levels similarly mice. Although high-fat–fed had higher counterparts, no sex difference detected capillarization. Metabolic functions perigonadal white (pgWAT) retained evidenced by smaller adipocytes preserved sensitivity, greater responsiveness isoproterenol, adiponectin lower ratio leptin:adiponectin mRNA. An enhanced browning HF-fed upregulation Ucp1 expression. PgWAT from augmented number cell markers, which associated mRNA pro-angiogenic mediators, including vascular factor A (Vegfa) its receptor (Vegfr2), Notch ligand Jagged-1 (Jag1) Angiopoietin-2 (Angpt2). Conclusions: Taken together, our findings provide novel display factors vascularity diet. is homeostasis at both levels. Our study discloses thus-far-unappreciated regulation angiogenesis may contribute an individual’s susceptibility developing dysfunction obesity-related disturbances.