Effects of angiotensin II receptor blockade on remnant glomerular permselectivity

摘要: This study examined the mechanisms by which angiotensin II (Ang II) receptor blockade improves glomerular barrier function in rats with reduced nephron number. Proteinuria was measured at four weeks after 5/6 renal ablation, and were then divided into a group received Ang blocker MK954 no treatment. Studies performed one week later showed that proteinuria without altering GFR ablated rats. Micropuncture studies both mean arterial pressure (142 +/- 7 mm Hg, ablation treatment; 105 2 treatment) transcapillary (54 3 43 1 treatment). Dextran sieving untreated developed size-selective defect characterized increased transglomerular passage of neutral dextrans radii 54 to 76 A charge-selective an anionic dextran sulfate radius approximately 18 A. fractional clearance values for large near observed normal but had effect on (0.68 0.11, 0.66 0.08, 0.46 0.05, rats). These findings indicate reducing activity size-selectivity affecting charge-selectivity injured remnant glomeruli.