Impact of pneumococcal conjugate vaccine on infections caused by antibiotic‐resistant Streptococcus pneumoniae

摘要: Studies have shown that vaccination with seven-valent pneumococcal conjugate vaccine (PCV7) results in a decline nasopharyngeal carriage of penicillin-resistant Streptococcus pneumoniae, vaccine-type pneumococci, and replacement by non-vaccine serotypes. Vaccines can reduce resistance vaccinated unvaccinated populations reducing the antibiotic-resistant serotypes, which protects population prevents spread disease to others, decreasing antibiotic through overall reduction use. However, while level serotypes drug-resistant nasopharynx, PCV7 also causes pneumococci replacement. The impact serotype on is not clearly understood. Pelton et al. surveyed two communities shortly after introduction immunization programme found colonization declined from 22% 2% 2000 2003, prevalence increased 7% 16%. Although colonizing S. pneumoniae isolates initially declined, penicillin-intermediate 2 years following introduction. change was primarily accounted for an increase 19A. Serotype 19A only affected prevalent worldwide, clinically important, highly multidrug-resistant. A study Hicks established as predominant post-PCV7 cause invasive (IPD) children elderly. An IPD rates caused occur without vaccination; reports indicate increases regions characterized extensive use, underscoring importance strategies contain resistance.