DNA Damage Responses in Atherosclerosis

摘要: DNA damage exists in all cellular organisms. While is distinguished from mutation, mutation can result unrepaired DNA. most be repaired, such repair systems are not 100% efficient. Un-repaired accumulates non-replicating cells, as neurons or myocytes of adult mammals, and cause aging. subdivided into two types: (1) endogenous caused by reactive oxygen species (ROS) that derived metabolic byproducts (2) exogenous radiation (UV, X-ray, gamma), hydrolysis, plant toxins, viruses. Current data suggest increased oxidative stress a major characteristic hypercholesterolemia-induced atherosclerosis likely associated with the development cholesterol-induced plaques. This chapter critically addresses extent to which damage, sensing it, involved pathogenesis atherosclerosis.