Neural substrates underlying motor skill learning in chronic hemiparetic stroke patients

摘要: Motor skill learning is critical in post-stroke motor recovery, but little known about its underlying neural substrates. Recently, using a new visuomotor paradigm involving speed/accuracy trade-off healthy individuals we identified three subpopulations based on their behavioral trajectories: fitters (in whom improvement speed or accuracy coincided with deterioration the other parameter), shifters and/or improved without degradation of and non-learners. We aimed to identify substrates first stages chronic hemiparetic stroke patients determine whether specific were recruited versus fitters. During functional magnetic resonance imaging (fMRI), 23 learned paretic upper limb. In whole-group analysis, correlation between activation was restricted dorsal prefrontal cortex damaged hemisphere (DLPFCdamh: r=-0.82) premotor (PMddamh: r=0.70); correlations much lesser (-0.160.25) regions interest. subgroup significant bilateral posterior parietal cortices did not correlate learning. Conversely, occurred primary sensorimotor cortexdamh supplementary areadamh PMd where changes correlated significantly (r=0.91). Finally, resting-state activity acquired before showed higher connectivity salience network compared (qFDR<0.05). These data suggest neuroplastic compensatory reorganization brain limb patients, key role