Streptozotocin induced hyperglycemia stimulates molecular signaling that promotes cell cycle reentry in mouse hippocampus

摘要: Abstract Aims Cerebral atrophy resulting from neurodegeneration is highly prevalent in individuals with diabetes; however, the underlying mechanisms for diabetic are not fully understood. Here we hypothesized that hyperglycemia induces molecular signaling favors induction of proliferation post mitotic, differentiated hippocampal neurons. Materials and methods Streptozotocin (150 mg/kg) was intraperitoneally injected to four months old male mice induce diabetes. Hippocampal tissue subjected analysis wingless-related integration site, extracellular signal regulated kinase, brain derived neurotrophic factor signaling, cell cycle regulation. Key findings Hyperglycemia did alter site or cyclin E levels hippocampus. There were reductions kinase activation along elevated D1 levels. Significance These indicate hyperglycemic conditions can stimulate progression hippocampus vivo. new insights into disease could support development novel therapeutics aimed provide neuroprotection patients.