Cisatracurium: myographical and electrophysiological studies in the isolated rat muscle

摘要: Myographical and electrophysiological studies of cisatracurium were performed, in vitro, the isolated sciatic nerve-extensor digitorum longus muscle preparation rat. Indirect twitches generated at 0.1 Hz tetanic contractions 50 Hz. endplate potentials (epps) trains The variables used analysis epps were: amplitude first epp train, average 30 degrees to 59 train (epps-plateau), rundown (percent loss epps-plateau relative train), quantal size content. myographical results showed that inhibitory concentration 50% (IC(50)) for blockade (0.48 microm) is 12 times its IC(50) induction fade (0.04 microm). a dependent decrease amplitudes two concentrations (0.13 microm 0.38 was intensified only presence higher (0.38 cisatracurium. In 0.13 (a which affects contractions, inducing their fade, while leaving twitch unaffected) there content train. microm), concentration, twitch, epps-plateau, but not indicate contraction induced by entirely because pre-synaptic blocking effect due post-synaptic effect.