A NOVEL SYNTHESIS OF 4-(5-SUBSTITUTED AMINOMETHYL)-1H-TETRAZOL-1-YL) BENZONITRILES

摘要: Objective: Synthesis of novel 4-(5-substituted amino methyl)- 1H -tetrazol-1-yl)benzonitriles from p-aminobenzonitrile Methods: A series 6(a-f) were prepared starting 1 which is protected with acetoxyacetylchloride, and followed by tetrazole formation CH 3 SiN in DIAD/TPP conditions to form the 1-(4-cyanophenyl)- -tetrazol-5-yl) methyl acetate . This compound was hydrolyzed, chlorination treated different amines produce title compounds. Results : All structures newly synthesized compounds confirmed IR, NMR, mass spectral studies, elemental analyses. Conclusion: We developed a simple efficient method for preparation through protection, formation, hydrolysis, amination as key steps good yields this highly useful synthesis biologically potent substituted derivatives.