Targeting the brain: various approaches and science involved

摘要: The brain targeting drug delivery system is the technique and process to deliver into or central nerves (CNS). main problem arise during in case of several related diseases disorders such as CNS malignancy, abscess, multiple sclerosis, schizophrenia etc. selective limiting permeation nature barriers i.e. blood barrier (BBB) cerebrospinal fluid (BCSF), these two only allow highly lipophilic molecule enters one greatest clinical impediment treatment disorders.  To treated this type drugs are targeted must be cross they’re by different types approaches used delivered molecules.Aim research. aim review paper compile all approaches, strategies techniques for a single paper/ article.Material method. prepare manuscript, various keywords were searched engines Google, Yahoo Bing available information public domain was collected classified according system. This deals with current enhance – invasive, non- invasive miscellaneous techniques, using easily across BBB BCSF.Result. CNS. All described applied overcoming problems that arises diseases. has list models (In-vitro In-vivo) study delivery.Conclusions. Drug treating very difficult challenging because molecules pass through BCSF. Overcome difficulties challenges certain non-invasive, intranasal drug, ocular focused ultrasound targeting. They help penetrate CSF efficacy treatment. article covered past five ten years. These proteins, peptides, amino acids,