Impact of radiation dose in postoperative radiotherapy after R1 resection for extrahepatic bile duct cancer: long term results from a single institution.

摘要: // Byoung Hyuck Kim 1,4 , Eui Kyu Chie 1 Kyubo 5 Jin-Young Jang 2 Sun Whe Do-Youn Oh 3 Yung-Jue Bang and Sung W. Ha Department of Radiation Oncology, Seoul National University College Medicine, Seoul, Republic Korea Surgery, Internal 4 Division Biological Warfare Preparedness Response, Armed Forces Medical Research Institute, Daejeon, Ewha Womans School Correspondence to: Chie, email: Keywords : extrahepatic bile duct cancer, R1 resection, postoperative radiotherapy, radiation dose Received September 18, 2016 Accepted April 10, 2017 Published 21, Abstract Purpose: This study was conducted to evaluate the impact after margin involved resection in patients with cancer. Methods: Among 251 who underwent curative followed by adjuvant chemoradiotherapy, 86 had either invasive carcinoma ( n = 63) or situ 23) at resected margin. them, 54 received conventional (40-50.4 Gy) 32 escalated (54-56 Gy). Results: Escalated associated improved locoregional control (5yr rate, 73.8% vs . 47.1%, p 0.069), but not disease-free survival 43.4% 32.6%, 0.490) overall 40.6% 29.6%, 0.348). In multivariate analysis for control, (HR 2.957, 0.032) 0.394, 0.047) were independent prognostic factors. No additional gastrointestinal toxicity observed group. Conclusions: Delivery ≥ Gy well tolerated resection. Further validation is warranted.