Semaphorin signals tweaking the tumor microenvironment.

摘要: Solid tumors not only comprise malignant cells but also other nonmalignant cell types, forming a unique microenvironment that can strongly influence the behavior of tumor cells. Recent advances in understanding cancer biology have highlighted functional role semaphorins. In fact, semaphorins form family molecular signals known to guide and control migration during embryo development adults. Tumor express as well their receptors, plexins neuropilins. It has been shown semaphorin signaling regulate behavior. Moreover, are important regulators angiogenesis. Conversely, very little is about relevance for tumor-infiltrating stromal cells, such leukocytes. this chapter, we review current knowledge on progression, focus emerging mediating cross talk between different