CSF biomarkers in suicide attempters – a principal component analysis
作者： D. Lindqvist , S. Janelidze , S. Erhardt , L. Träskman-Bendz , G. Engström
DOI: 10.1111/J.1600-0447.2010.01655.X
关键词:
摘要: Lindqvist D, Janelidze S, Erhardt Traskman-Bendz L, Engstrom G, Brundin L. CSF biomarkers in suicide attempters - a principal component analysis. Objective: The objective of the present study was to identify biological patterns (factors) among 20 cerebrospinal fluid (CSF) and subsequently analyse their association with suicidal behaviour. Method: We measured kynurenic acid, orexin, homovanillic acid (HVA), 5-hydroxyindoleacetic (5-HIAA), 3-methoxy-4-hydroxyphenylglycol, chemokines, matrix metalloproteases cytokines 124 drug-free attempters. Patients were evaluated for suicidality psychiatric symptoms using well-defined rating scales followed-up regarding future suicide. used analysis factors substances. Results: Four extracted from biomarkers, explaining 52.4% total variance. Factors 1 2 characterized by high loadings chemokines respectively. They both associated severe depressive symptoms. Factor also intent. 4 strong monoamine metabolites 5-HIAA HVA, as well orexin interleukin-6. High scores on this factor found patients who performed violent attempt completed Conclusion: Our results suggest that specific combinations may discriminate between types behaviour indicate increased risk (Less)
sci-hub.se 参考文章(63)
Gunnar Engström, Christer Alling, Kaj Blennow, Göran Regnéll, Lil Träskman-Bendz, Reduced cerebrospinal HVA concentrations and HVA/5-HIAA ratios in suicide attempters. Monoamine metabolites in 120 suicide attempters and 47 controls. European Neuropsychopharmacology. ,vol. 9, pp. 399- 405 ,(1999) , 10.1016/S0924-977X(99)00016-4
Lil Träskman-Bendz, Barbara Stanley, M. Stanley, The suicide assessment scale: a scale evaluating change in suicidal behavior. Psychopharmacology Bulletin. ,vol. 22, pp. 200- 205 ,(1986)
Christelle Peyron, Juliette Faraco, William Rogers, Beth Ripley, Sebastiaan Overeem, Yves Charnay, Sona Nevsimalova, Michael Aldrich, David Reynolds, Roger Albin, Robin Li, Marcel Hungs, Mario Pedrazzoli, Muralidhara Padigaru, Melanie Kucherlapati, Jun Fan, Richard Maki, Gert Jan Lammers, Constantin Bouras, Raju Kucherlapati, Seiji Nishino, Emmanuel Mignot, None, A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains Nature Medicine. ,vol. 6, pp. 991- 997 ,(2000) , 10.1038/79690
Álvaro González, Nerea Varo, Estibaliz Alegre, Angel Díaz, Ignacio Melero, Immunosuppression routed via the kynurenine pathway: a biochemical and pathophysiologic approach. Advances in Clinical Chemistry. ,vol. 45, pp. 155- 197 ,(2008) , 10.1016/S0065-2423(07)00007-8
Lil Träskman‐Bendz, Marie Åsberg, Leif Bertilsson, Peter Nordström, Conny Nordin, Mats Samuelsson, Anna Åberg‐Wistedt, CSF 5-HIAA Predicts Suicide Risk after Attempted Suicide. Suicide and Life Threatening Behavior. ,vol. 24, pp. 1- 9 ,(1994) , 10.1111/J.1943-278X.1994.TB00657.X
Kirsi Suominen, Erkki Isometsä, Aini Ostamo, Jouko Lönnqvist, Level of suicidal intent predicts overall mortality and suicide after attempted suicide: a 12-year follow-up study BMC Psychiatry. ,vol. 4, pp. 11- 11 ,(2004) , 10.1186/1471-244X-4-11
A MARQUESDEAK, F NETO, W DOMINGUEZ, A SOLIS, D KURCGANT, F SATO, J ROSS, E PRADO, Cytokine profiles in women with different subtypes of major depressive disorder. Journal of Psychiatric Research. ,vol. 41, pp. 152- 159 ,(2007) , 10.1016/J.JPSYCHIRES.2005.11.003
Seiji Nishino, Beth Ripley, Sebastiaan Overeem, Sona Nevsimalova, Gert Jan Lammers, Jitka Vankova, Michele Okun, William Rogers, Stephen Brooks, Emmanuel Mignot, Low cerebrospinal fluid hypocretin (orexin) and altered energy homeostasis in human narcolepsy Annals of Neurology. ,vol. 50, pp. 381- 388 ,(2001) , 10.1002/ANA.1130
Leo Sher, J. John Mann, Lil Traskman-Bendz, Ronald Winchel, Yung-yu Huang, Eric Fertuck, Barbara H. Stanley, Lower cerebrospinal fluid homovanillic acid levels in depressed suicide attempters Journal of Affective Disorders. ,vol. 90, pp. 83- 89 ,(2006) , 10.1016/J.JAD.2005.10.002
N.M. Simon, K. McNamara, C.W. Chow, R.S. Maser, G.I. Papakostas, M.H. Pollack, A.A. Nierenberg, M. Fava, K.K. Wong, A Detailed Examination of Cytokine Abnormalities in Major Depressive Disorder European Neuropsychopharmacology. ,vol. 18, pp. 230- 233 ,(2008) , 10.1016/J.EURONEURO.2007.06.004