Non-alcoholic steatohepatitis: emerging molecular targets and therapeutic strategies

摘要: Non-alcoholic fatty liver disease—the most common chronic liver disease—encompasses a histological spectrum ranging from simple steatosis to non-alcoholic steatohepatitis (NASH). Over the next decade, NASH is projected to be the most common indication for liver transplantation. The absence of an effective pharmacological therapy for NASH is a major incentive for research into novel therapeutic approaches for this condition. The current focus areas for research include the modulation of nuclear transcription factors; agents that target …