Epstein-Barr virus growth/latency III program alters cellular microRNA expression.
作者： Jennifer E. Cameron , Claire Fewell , Qinyan Yin , Jane McBride , Xia Wang
DOI: 10.1016/J.VIROL.2008.09.018
关键词:
摘要: The Epstein-Barr virus (EBV) is associated with lymphoid and epithelial cancers. Initial EBV infection alters lymphocyte gene expression, inducing cellular proliferation differentiation as the transitions through consecutive latency transcription programs. Cellular microRNAs (miRNAs) are important regulators of signaling pathways implicated in carcinogenesis. extent to which exploits miRNAs unknown. Using micro-array analysis quantitative PCR, we demonstrate differential expression type III versus I including elevated miR-21, miR-23a, miR-24, miR-27a, miR-34a, miR-146a b, miR-155. In contrast, miR-28 was found be lower latency. EBV-mediated regulation may contribute
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