Anti-endotoxin antibodies
作者： Müller-Loennies Sven , Padova Di Franco , Brade Lore , Brade Helmut , Rietschel Th. Ernst
DOI: 10.1007/978-3-7985-1729-5_17
关键词:
摘要: Lipopolysaccharid (LPS, Endotoxin) ist ein potenter Aktivator der angeborenen Immunantwort und lost die Freisetzung einer Vielzahl proinflammatorischer Mediatoren aus. Diese unkontrollierte Immunreaktion fur den lebensbedrohlichen Zustand von Sepsis-Patienten verantwortlich. Eine erfolgreiche Strategie zur Behandlung Gram-negativen Sepsis muss daher neben antiinfektiosen Therapie, d.h. Eliminierung Erreger durch konventionelle Antibiotika, eine antiendotoxische Neutralisation Wirkung LPS, beinhalten.
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