Depletion of Antibody-Forming Cells and Their Precursors from Complex Lymphoid Cell Populations

摘要: Lymphocytes are now known to be a heterogeneous cell population which contains at least two functional subtypes. One subtype of (B-lymphocyte) bears easily detectable amounts membrane-associated immunoglobulin; studies in mice have established that these lymphocytes bone marrow origin and include the precursors antibody-forming cells (1, 2, 3). A small number within this surface immunoglobulin bearing from non-immunized animals specifically bind antigen frequency such increases subsequent immunization (4, 5). The other major lacks mediates variety cellular immune phenomena (6, 7). These mouse derived thymus possess differentiation antigens, as θ, allow their identification (1). Further delineation structure function lymphocyte subpopulation interactions between them would aided by development techniques obtain relatively pure populations.