Relation of Estrogen and Its Receptor to Rat Liver Growth and Regeneration

摘要: A variety of hormones have been implicated in the process liver regeneration. Despite demonstration specific estrogen receptors (ER) mammalian and identification responses to which occur liver, there has little or no investigation relation that hormone its receptor regeneration growth. This report provides information indicates: ( a ) effect 17β-estradiol on mass both intact regenerating rat liver; b percentage hepatocytes neonatal adult normal livers contain ER, i.e. , index (ERI); c changes ERI nuclear ER occurring cell population following partial hepatectomy (PH) and/or administration; d temporal with those related DNA synthesis growth. Approximately 55 60% parenchymal cells from rats were found was entirely located cytoplasm. No evident such cells. By 1 hr, subsequently administration animals, resulted depletion number ER-containing ER. These followed by onset increased an increase weight p < 0.001). Subsequent 70% PH, similar series events occurred remnants. Not only decrease at time PH 40% 3 hr later 30% after 72 cytosol as well. Accompanying 24 post-PH, 29% displayed their nuclei. At time, peak, taking place. When administered more rapid translocation nuclei when given, One later, 18% had contrast finding 3% post-PH not administered. Regeneration greater (59 versus 73%; = 0.003) animals received prior PH. Findings growing consonant observed remnants PH. The 5-day-old 9%. That value maturity, reaching levels month (65%). Concomitantly, labeling index, indicative synthesis, decreased 5% 1-month-old animals. The sequence events, appearance restoration mass, these investigations, they are considered light observations others, permits formulation hypothesis relates hepatic growth neonate.