Reduction of Plasma Gelsolin Levels Correlates with Development of Multiple Organ Dysfunction Syndrome and Fatal Outcome in Burn Patients

摘要: Background Depletion of the circulating actin-binding protein, plasma gelsolin (pGSN) has been described in critically ill surgical patients. We hypothesized that extent pGSN reduction might correlate with different outcome burn The study was performed to evaluate prognostic implications levels on development multiple organ dysfunction syndrome (MODS) and fatal a group severely patients. Methods Findings 95 patients were included, they divided into three groups area: I (n = 33), II 32) III 30). According whether there MODS or not, 28) none-MODS 67); then further non-survivor 17) survivor 11). peripheral blood samples collected postburn days (PBD) 1, 3, 7, 14, 21. determined T cells procured from blood. contents cytokines (IL-2, IL-4 IFN-γ) released by also measured. related factors prognosis analyzed using multivariate logistic regression analysis. results showed concentrations, as well IL-2 IFN-γ, decreased markedly PBD 1–21, whereas, increased all compared normal controls (P<0.05 P<0.01), obviously differences between P<0.01). similar found those without survival 3–21 Moreover, decreased, incidence septic complication remarkably increased. Conclusions pGSN appear be an early marker suffering major burns.