Direct evidence for the specific fixation of Cl. botulinum A neurotoxin to brain matter.
作者： E. Habermann , Irmtraud Heller
DOI: 10.1007/BF00632641
关键词:
摘要: Rat brain homogenate and synaptosomes from rat bind botulinum toxin. The binding is accompanied by partial inactivation. decreases with increasing ionic strength. A considerable fixation of tetanus toxin can still be demonstrated under conditions which prevent the 2. Only grey substance, not white substance bovine able to 3. Upon pretreatment neuraminidase, lose nearly all their capacity. However, neither gangliosides nor ganglioside-cerebroside mixtures extracts could replace synaptosomes. Thus closely resembles in its ability react (a) neuraminidase-sensitive site(s) matter CNS. It differs stronger sensitivity against forces failure certain gangliosides.
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