Microsatellite instability (MSI) increases with age in normal somatic cells

作者: Mary I. Coolbaugh-Murphy , Jingping Xu , Louis S. Ramagli , Barry W. Brown , Michael J. Siciliano

DOI: 10.1016/J.MAD.2005.06.005

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摘要: … We use SP-PCR to evaluate the level of MSI at six loci in PBLs from 17 normal blood bank volunteers ranging in age from 20 to 67 y/o. We will show chromatograms to demonstrate the …

参考文章(26)
William S. Cleveland, Susan J. Devlin, Locally Weighted Regression: An Approach to Regression Analysis by Local Fitting Journal of the American Statistical Association. ,vol. 83, pp. 596- 610 ,(1988) , 10.1080/01621459.1988.10478639
Gaëlle Bougeard, Françoise Charbonnier, Alexandre Moerman, Cosette Martin, Marie M. Ruchoux, Nathalie Drouot, Thierry Frébourg, Early onset brain tumor and lymphoma in MSH2-deficient children. American Journal of Human Genetics. ,vol. 72, pp. 213- 216 ,(2003) , 10.1086/345297
Lin Zhang, Esther P. Leeflang, Jian Yu, Norman Arnheim, Studying human mutations by sperm typing: instability of CAG trinucleotide repeats in the human androgen receptor gene. Nature Genetics. ,vol. 7, pp. 531- 535 ,(1994) , 10.1038/NG0894-531
R. Parsons, G. Li, M. Longley, P. Modrich, B. Liu, T. Berk, Hamilton, K. Kinzler, B. Vogelstein, Mismatch repair deficiency in phenotypically normal human cells Science. ,vol. 268, pp. 738- 740 ,(1995) , 10.1126/SCIENCE.7632227
Lauri A Aaltonen, Päivi Peltomäki, Fredrick S Leach, Pertti Sistonen, Lea Pylkkänen, Jukka-Pekka Mecklin, Heikki Järvinen, Steven M Powell, Jin Jen, Stanley R Hamilton, Gloria M Petersen, Kenneth W Kinzler, Bert Vogelstein, Albert De La Chapelle, Clues to the pathogenesis of familial colorectal cancer Science. ,vol. 260, pp. 812- 816 ,(1993) , 10.1126/SCIENCE.8484121
J Vijg, Somatic mutations and aging: a re-evaluation. Mutation Research. ,vol. 447, pp. 117- 135 ,(2000) , 10.1016/S0027-5107(99)00202-X
Mary Coolbaugh-Murphy, Atousa Maleki, Lou Ramagli, Marsha Frazier, Benjamin Lichtiger, Darren G. Monckton, Michael J. Siciliano, Barry W. Brown, Estimating mutant microsatellite allele frequencies in somatic cells by small-pool PCR. Genomics. ,vol. 84, pp. 419- 430 ,(2004) , 10.1016/J.YGENO.2004.03.007
Paweł Stankiewicz, Christine J. Shaw, Jason D. Dapper, Keiko Wakui, Lisa G. Shaffer, Marjorie Withers, Leah Elizondo, Sung-Sup Park, James R. Lupski, Genome architecture catalyzes nonrecurrent chromosomal rearrangements. American Journal of Human Genetics. ,vol. 72, pp. 1101- 1116 ,(2003) , 10.1086/374385
Aytemiz Gürgey, Özden Uzunalimoğlu, Tayfun Özçelik, Marie D. Ricciardone, Murat Tuncer, Eren Erken, Hilal Özdağ, Hülya Çetinkaya, Attila Tanyeli, Birsen Cevher, Mehmet Öztürk, Human MLH1 Deficiency Predisposes to Hematological Maligancy and Neurofibromatosis Type 1 Cancer Research. ,vol. 59, pp. 290- 293 ,(1999)