Host genetic factors in resistance and susceptibility to malaria.

摘要: Well-controlled genetic studies are easier to conduct with mice than humans, and it has long been known that certain strains of consistently show a greater degree resistance infection other strains. It is clear these differences primarily genetic, rather environmental or acquired. This chapter discusses specific loci have identified as responsible for some differences. Genetic factors also appear underlie striking in malaria observed between ethnic groups who live the same area. The deals growing list genes evidence influencing malaria. Glycophorins A B, encoded by homologous GYPA GYPB, major sialoglycoproteins erythrocyte membrane, which carries antigenic determinants various blood groups. Hemoglobin S (HbS) homozygotes sickle cell disease, debilitating often fatal disorder caused red deformities result from this structural defect, particularly at low oxygen concentrations. thalassemias group disorders due defective production α- β- globin chains, arising diverse set deletions disruptions gene clusters on chromosomes 11 16. Haptoglobin, HP gene, protein found plasma. Parasite sequestration cerebral capillaries, hallmark human malaria, notable its absence Plasmodium berghei ANKA (PBA) experimental model.