External beam and conformal radiotherapy in the management of gliomas

摘要: External beam radiotherapy remains an important local treatment modality in both high and low grade gliomas, however its contribution to outcome modest. In tumours this is because of their extreme clinical radioresistance, with recurrences occurring even after doses over 70 Gy. radiation does not seem alter the overall pattern disease progression significantly. Therefore despite use new technologies now available that allow be delivered more accurately higher doses, control these still rarely achieved. Unfortunately have proven sensitive changes fractionation or addition radio-sensitising agents. Novel approaches are needed, based on improved understanding tumour normal tissue response radiation.