Learning and Representation of Declarative Memories by Single Neurons in the Human Brain

作者: Ueli Rutishauser

DOI: 10.7907/GX3N-QD05.

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摘要: Episodic memories allow us to remember not only that we have seen an item before but also where and when it (context). Neurons in the medial temporal lobe (MTL) are critically involved acquisition of such memories. Since events happen once, ability distinguish novel from familiar stimuli is crucial order rapidly encode after a single exposure. Theoretically, this hard learning problem (single-trial learning). Yet, successful detection novelty necessary for many types learning. During retrieval, can sometimes confidently report something (familiarity) cannot recollect or was seen. Thus episodic several components which be recalled selectively. We recorded neurons local field potentials human hippocampus, amygdala, anterior cingulate cortex while subjects remembered, later retrieved, identity location pictures shown. describe two classes exhibit single-trial learning: familiarity detectors, show selective increase firing new old stimuli, respectively. The retain memory stimulus at least 24 h. these will successfully recollected recollected. Similarly, they between failed recognition. Pictures were forgotten by patient still evoked non-zero response. Thus, their response different decision patient. Also, demonstrate listening (during retrieval) enables simple decoder outperform (i.e., forgets fewer pictures). These data support continuous strength model MTL function: stronger neuronal response, better (as opposed dual-process model). I specific power increases frequencies potential predictive retrieval success. neural signatures, during learning, thus indicate whether plasticity not.

参考文章(373)
H. Miyakawa, Zhixiong Chen, H. Furuse, H. Sasaki, H. Kato, K.-I. Ito, M. Miura, K. Kaneko, S. Fujii, Roles of dopamine receptors in long-term depression: enhancement via D1 receptors and inhibition via D2 receptors. Receptors & Channels. ,vol. 4, pp. 1- 8 ,(1996)
David G. Amaral, Norio Ishizuka, Brenda Claiborne, Chapter 1 Chapter Neurons, numbers and the hippocampal network Progress in Brain Research. ,vol. 83, pp. 1- 11 ,(1990) , 10.1016/S0079-6123(08)61237-6
Hanan Davidowitz, Naftali Tishby, William Bialek, Dima Rinberg, Spike sorting in the frequency domain with overlap detection arXiv: Data Analysis, Statistics and Probability. ,(2003)
David S. Olton, Matthew L. Shapiro, Hippocampal function and interference The MIT Press. ,(1994)
Robert T. Knight, Tsutomu Nakada, A Review of EEG and Blood Flow Data Reviews in The Neurosciences. ,vol. 9, pp. 57- 70 ,(1998) , 10.1515/REVNEURO.1998.9.1.57
Itzhak Fried, Charles L. Wilson, Nigel T. Maidment, Jerome Engel, Eric Behnke, Tony A. Fields, Katherine A. Macdonald, Jack W. Morrow, Larry Ackerson, Cerebral microdialysis combined with single-neuron and electroencephalographic recording in neurosurgical patients. Technical note. Journal of Neurosurgery. ,vol. 91, pp. 697- 705 ,(1999) , 10.3171/JNS.1999.91.4.0697
George Bachman, Lawrence Narici, Edward Beckenstein, Fourier and Wavelet Analysis ,(1999)
Gabriel Kreiman, Christof Koch, Itzhak Fried, Imagery neurons in the human brain Nature. ,vol. 408, pp. 357- 361 ,(2000) , 10.1038/35042575
O. Creutzfeldt, G. Ojemann, E. Lettich, Neuronal activity in the human lateral temporal lobe. II. Responses to the subjects own voice. Experimental Brain Research. ,vol. 77, pp. 476- 489 ,(1989) , 10.1007/BF00249601