作者: Ueli Rutishauser
DOI: 10.7907/GX3N-QD05.
关键词:
摘要: Episodic memories allow us to remember not only that we have seen an item before but also where and when it (context). Neurons in the medial temporal lobe (MTL) are critically involved acquisition of such memories. Since events happen once, ability distinguish novel from familiar stimuli is crucial order rapidly encode after a single exposure. Theoretically, this hard learning problem (single-trial learning). Yet, successful detection novelty necessary for many types learning. During retrieval, can sometimes confidently report something (familiarity) cannot recollect or was seen. Thus episodic several components which be recalled selectively. We recorded neurons local field potentials human hippocampus, amygdala, anterior cingulate cortex while subjects remembered, later retrieved, identity location pictures shown. describe two classes exhibit single-trial learning: familiarity detectors, show selective increase firing new old stimuli, respectively. The retain memory stimulus at least 24 h. these will successfully recollected recollected. Similarly, they between failed recognition. Pictures were forgotten by patient still evoked non-zero response. Thus, their response different decision patient. Also, demonstrate listening (during retrieval) enables simple decoder outperform (i.e., forgets fewer pictures). These data support continuous strength model MTL function: stronger neuronal response, better (as opposed dual-process model). I specific power increases frequencies potential predictive retrieval success. neural signatures, during learning, thus indicate whether plasticity not.