Differential Regulation of Murine T Lymphocyte Subsets

摘要: T lymphocytes play a central role in immune responses. Many of the effector and regulatory functions are carried out by secreted iymphokines, characteristics specific responses determined to large extent particular arrays Iymphokines that produced. CD4+ cells have been categorized into two distinct subsets based on pattern lymphokine secretion; TH1 produce IL-2 IFN-y (and other Iymphokines) but not IL-4, IL-5, IL-6, or IL-10 while TH2 (Mosmann Coffman 1989). These also functional differences: mediate delayed-type hypersensitivity provide efficient “help” for B The some vivo appear relate dominance subsets. For example, experimental leishmania infections mice, TH1-type response predominates mouse strains resistant infection, whereas TH2-type susceptible progressive infection (Heinzel et al. 1989)