Loss of heterozygosity on chromosome 1p in thyroid adenoma and medullary carcinoma, but not in papillary carcinoma.
作者： Katsuyuki Kubo , Katsuhiko Yoshimoto , Yutaka Yokogoshi , Masaru Tsuyuguchi , Shiro Shiro
DOI: 10.1111/J.1349-7006.1991.TB01763.X
关键词:
摘要: We analyzed 53 loci on 21 chromosomes other than chromosome 4 to detect possible loss of heterozygosity in 31 thyroid tumors using polymorphic DNA markers that allelic deletions at specific chromosomal loci. Loss 1, 7 and 12 was detected one follicular adenoma, 1 two medullary carcinomas. However, no any the examined papillary These results suggest adenoma is signals for risk premalignant transformation, inactivation unknown genes 1p contributes tumorigenesis carcinoma. Some genetic changes losses may participate
sci-hub.se 参考文章(37)
Maria T. Rojeski, Hossein Gharib, Nodular Thyroid Disease New England Journal of Medicine. ,vol. 313, pp. 428- 436 ,(1985) , 10.1056/NEJM198508153130707
Carl Miller, T. Mohandas, D. Wolf, M. Prokocimer, V. Rotter, H. Phillip Koeffler, Human p53 gene localized to short arm of chromosome 17 Nature. ,vol. 319, pp. 783- 784 ,(1986) , 10.1038/319783A0
E.M. Southern, Detection of specific sequences among DNA fragments separated by gel electrophoresis. Journal of Molecular Biology. ,vol. 98, pp. 503- 517 ,(1975) , 10.1016/S0022-2836(75)80083-0
Daniel A. Haber, Alan J. Buckler, Tom Glaser, Katherine M. Call, Jerry Pelletier, Robert L. Sohn, Edwin C. Douglass, David E. Housman, An internal deletion within an 11p13 zinc finger gene contributes to the development of Wilms' tumor. Cell. ,vol. 61, pp. 1257- 1269 ,(1990) , 10.1016/0092-8674(90)90690-G
Hideaki Mizoguchi, Masaaki Terada, Jun Yokota, Takashi Sugimura, Makio Wada, Infrequent loss of chromosomal heterozygosity in human stomach cancer. Cancer Research. ,vol. 48, pp. 2988- 2992 ,(1988)
N. Blin, D. W. Stafford, A general method for isolation of high molecular weight DNA from eukaryotes Nucleic Acids Research. ,vol. 3, pp. 2303- 2308 ,(1976) , 10.1093/NAR/3.9.2303
LEWIS B. WOOLNER, WILLIAM M. McCONAHEY, OLIVER H. BEAHRS, STRUMA LYMPHOMATOSA (HASHIMOTO'S THYROIDITIS) AND RELATED THYROIDAL DISORDERS The Journal of Clinical Endocrinology and Metabolism. ,vol. 19, pp. 53- 83 ,(1959) , 10.1210/JCEM-19-1-53
Lennart Bondeson, Allan Bengtsson, Anne-Greth Bondeson, Rigmor Dahlenfors, Lars Grimelius, Barbro Wedell, Joachim Mark, Chromosome studies in thyroid neoplasia. Cancer. ,vol. 64, pp. 680- 685 ,(1989) , 10.1002/1097-0142(19890801)64:3<680::AID-CNCR2820640319>3.0.CO;2-I
Cathy A. Finlay, Philip W. Hinds, Arnold J. Levine, The p53 proto-oncogene can act as a suppressor of transformation Cell. ,vol. 57, pp. 1083- 1093 ,(1989) , 10.1016/0092-8674(89)90045-7
S Nishimura, T Sekiya, Human cancer and cellular oncogenes. Biochemical Journal. ,vol. 243, pp. 313- 327 ,(1987) , 10.1042/BJ2430313