Glucose metabolism in patients with acute myocardial infarction and no previous diagnosis of diabetes mellitus: a prospective study

摘要: Summary Background Glycometabolic state at hospital admission is an important risk marker for long-term mortality in patients with acute myocardial infarction, whether or not they have known diabetes mellitus. Our aim was to ascertain the prevalence of impaired glucose metabolism without diagnosed but and assess such abnormalities can be identified early course a infarction. Methods We did prospective study, which we enrolled 181 consecutive admitted coronary care units two hospitals Sweden no diagnosis diabetes, blood concentration less than 11·1 mmol/L. recorded concentrations during stay, standardised oral tolerance tests 75 g discharge again 3 months later. Findings The mean age our cohort 63.5 years (SD 9) 6·5 mmol/L (1·4). 2-h postload 9.2 (2·9) discharge, 9·0 (3.0) 58 164 (35%, 95% CI 28–43) 144 (40%, 32–48) individuals had after months, respectively, 51 (31%, 24–38) 36 (25%, 18–32) previously undiagnosed Independent predictors abnormal were HbA 1c (p=0·024) fasting on day 4 (p=0·044). Interpretation Previously are common These detected postinfarction period. results suggest that postchallenge hyperglycaemia phase infarction could used as markers high-risk individuals.