Do anabolic nutritional supplements stimulate human growth hormone secretion in elderly women with heart failure

作者: Ellen THC Smeets , Scott E Schutzler , Jeanne Y Wei , Gohar Azhar , Robert R Wolfe

DOI: 10.14814/PHY2.13366

关键词:

摘要: Abstract Growth hormone treatment has gained attention over the past decade as a for heart failure. Human growth (HGH) must be administered by injections (usually daily), so there is considerable advantage to stimulation of endogenous secretion amino acid‐based nutritional supplementation. However, studies investigating effect acid (AA) supplementation show conflicting results. Therefore, in this study we aimed investigate on HGH production elderly women with Eight failure participated randomized cross‐over study. Plasma concentration was measured before and 4 h following ingestion mixture protein, carbohydrate, fat or an AA beverage. determined ELISA kits concentrations were analyzed Liquid Chromatography–Mass Spectrometry (LCMS). Linear mixed models performed analyze time, treatment, interaction. arginine lysine significantly higher after consumption drink compared fat. Nonetheless, only (meal replacement) increased concentration. meal replacement containing Consumption acids failed increase despite greater elevations plasma concentrations, including lysine. The stimulatory protein/carbohydrate/fat presumably mediated factors other than increases free concentrations.

参考文章(28)
James A. de Lemos, Rebecca Vigen, Keeping the genie in the bottle: growth hormone and cardiovascular disease. Journal of the American College of Cardiology. ,vol. 64, pp. 1461- 1463 ,(2014) , 10.1016/J.JACC.2014.05.070
R.C. Jenkins, R.J.M. Ross, 8 Acquired growth hormone resistance in adults Baillière's clinical endocrinology and metabolism. ,vol. 12, pp. 315- 329 ,(1998) , 10.1016/S0950-351X(98)80025-6
Carlo Lombardi, Valentina Carubelli, Valentina Lazzarini, Enrico Vizzardi, Filippo Quinzani, Federica Guidetti, Riccardo Rovetta, Savina Nodari, Mihai Gheorghiade, Marco Metra, Effects of oral amino acid supplements on functional capacity in patients with chronic heart failure Clinical Medicine Insights: Cardiology. ,vol. 8, pp. 39- 44 ,(2014) , 10.4137/CMC.S14016
Raffaele Napoli, Vincenzo Guardasole, Margherita Matarazzo, Emiliano A Palmieri, Ugo Oliviero, Serafino Fazio, Luigi Saccà, Growth hormone corrects vascular dysfunction in patients with chronic heart failure. Journal of the American College of Cardiology. ,vol. 39, pp. 90- 95 ,(2002) , 10.1016/S0735-1097(01)01707-7
Katsuaki Tanaka, Shuji Inoue, Junko Shiraki, Toshihiro Shishido, Mari Saito, Kazushi Numata, Yutaro Takamura, Age-related decrease in plasma growth hormone: response to growth hormone-releasing hormone, arginine, and L-dopa in obesity. Metabolism-clinical and Experimental. ,vol. 40, pp. 1257- 1262 ,(1991) , 10.1016/0026-0495(91)90025-R
Mariantonietta Cicoira, Paul R. Kalra, Stefan D. Anker, Growth hormone resistance in chronic heart failure and its therapeutic implications. Journal of Cardiac Failure. ,vol. 9, pp. 219- 226 ,(2003) , 10.1054/JCAF.2003.23
Annamaria Colao, The GH-IGF-I axis and the cardiovascular system: clinical implications. Clinical Endocrinology. ,vol. 69, pp. 347- 358 ,(2008) , 10.1111/J.1365-2265.2008.03292.X
PLASMA GROWTH HORMONE RESPONSE TO INTRAVENOUS ADMINISTRATION OF AMINO ACIDS. The Journal of Clinical Endocrinology and Metabolism. ,vol. 25, pp. 1140- 1144 ,(1965) , 10.1210/JCEM-25-8-1140