Relevance of Presynaptic Proteins to Neuropsychiatric Disorders

摘要: Schizophrenia is a psychiatric disorder that likely arises from complex series of interactions between genetic and environmental factors, resulting in altered neural connectivity. Consistent with this position, an extensive body research has demonstrated the molecular machinery regulates synaptic activity post mortem brain tissue schizophrenia. In particular, soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) synaptosomal-associated protein-25 (SNAP-25) SNARE-interacting proteins complexin I II are implicated pathophysiology disorder. These regulate neurotransmission important for plasticity-associated changes brain. Recent evidence our laboratory levels these decreased hippocampus schizophrenia, importantly, decreases significantly associated cognitive impairment. findings represent first description linking to function Preclinical studies provide SNAP-25 complexins may be additional neurological disorders, as well therapeutic efficacy drugs used treatment disorders.