Enhanced Gametocyte Formation by Plasmodium chabaudi in Immature Erythrocytes: Pattern of Production, Sequestration, and Infectivity to Mosquitoes

摘要: The objective of this study was to investigate the chronobiology and infectivity gametocytes Plasmodium chabaudi chabaudi. In order increase production gametocytes, mice were treated with phenylhydrazine induce a hyper-reticulocytosis. authors observed an important stimulation gametocytogenesis. Gametocytes seen as soon second day postinoculation produced periodically at each schizogony, every 24 hr. gametocytic developmental cycle lasted 60 hr consisted 4 successive stages: stage 0 36 hr, from merozoite invasion, I 42 II 48 III 54 An fraction sequestered in small peripheral capillaries. numbers oocysts mosquitoes fed on phenylhydrazine-treated larger than controls. When different times day, circadian differences oocyst counts not statistically significant. However, considered be probably most infective because, like gametocyte other species murine malaria, it is contrast vinckei, there no peak time sequestration stage; due inhibitory effect schizogony occurring time.