[Cardiovascular effects of beraprost sodium (TRK-100), a prostacyclin analogue in the dog].

摘要: Effect of prostacyclin analogue, beraprost sodium (Sodium (+/-)-(1R*, 2R*, 3aS*, 8bS*)-2, 3,3a,8b-tetrahydro-2-hydroxy-1-[(E)-(3S*)-3-hydroxy-4-methyl-1-octen+ ++-6- ynyl]-1H-cyclopenta-[b]benzofuran-5-butyrate, TRK-100), on the cardiovascular system anesthetized dog was investigated. TRK-100 injected intra-arterially and intravenously to study vasodilating effect drug by a magnetic flow meter. Intra-arterial injection augmented blood vertebral, coronary, renal, supramesenteric, hepatic femoral artery at dose range 0.0003 3,000 micrograms/bed. The threshold doses PGI2 in mesenteric were 0.003 micrograms micrograms, respectively, same values obtained splenic artery. Those slightly lower than those other arteries. Intravenous renal arterial 193 +/- 30% 118 4%, respectively. In this augmentation 179 19% 135 1%, while carotid, decreased, 71.4 2.1%, 80.0 9.4% 61.4 5.6% 70.6 5.6%, 79.5 6.9% 67.1 4.7% PGI2. Inhibitory effects heart functions such as cardiac output, left ventricular pressure, LV dP/dt, oxygen consumption, work seen. similar Coronary vascular resistance, total peripheral resistance systemic pressure also decreased