Isolation of a Common Receptor for Coxsackie B Viruses and Adenoviruses 2 and 5

作者: Jeffrey M Bergelson , Jennifer A Cunningham , Gustavo Droguett , Evelyn A Kurt-Jones , Anita Krithivas

DOI: 10.1126/SCIENCE.275.5304.1320

关键词:

摘要: A complementary DNA clone has been isolated that encodes a coxsackievirus and adenovirus receptor (CAR). When transfected with CAR DNA, nonpermissive hamster cells became susceptible to coxsackie B virus attachment infection. Furthermore, consistent previous studies demonstrating infection depends on of viral fiber the target cell, CAR-transfected bound in fiber-dependent fashion showed 100-fold increase susceptibility virus-mediated gene transfer. Identification as for these two unrelated structurally distinct pathogens is important understanding pathogenesis implications therapeutic delivery vectors.

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