Behavioural and electroencephalographic effects of systemic injections of 8-OH-DPAT in the pigeon (Columba livia)

摘要: Abstract The effects of systemic injections the 5HT 1A receptor agonist 8-OH-DPAT on spontaneous ingestive, maintenance, locomotor and sleep-like behaviours, sleep/waking-related hippocampal electrographic activity were investigated in pigeons. (0.06, 0.2, 0.6 or 2.0 mg/kg) was found to dose-dependently reduce food water intake, acutely (in first 3 h) 24 h after treatment, during both low-activity morning hours (starting at 10:00 h) high-activity evening 14:00 h). Automated records intake indicated that hypophagic can last up 18 h injection. Duration incidence postures increased all doses, afternoon. These associated with decreases exploratory preening activities. 8-OH-DPAT-induced hypnogenic, hypodipsic tended be more intense than afternoon-trials. Pretreatment WAY 100635 (a 5-HT antagonist; 0.6 mg/kg) eliminated these effects. failed affect feeding when injected alone, but decreased frequency responses latency episode. Hippocampal EEG tracings (0.6 hypnogenic are a specific increase duration slow wave sleep. Power density analysis show differences between sleep occurring vehicle injections, indicating it may electrographically similar diurnal episodes pigeon. data suggest while 1a receptor-mediated mechanisms play crucial roles ingestive sleep/waking behaviours mammals birds, their action upon states shows substantial inter-taxon variance.