Editor's Highlight: Congener-Specific Disposition of Chiral Polychlorinated Biphenyls in Lactating Mice and Their Offspring: Implications for PCB Developmental Neurotoxicity.

摘要: Chiral polychlorinated biphenyl (PCB) congeners have been implicated by laboratory and epidemiological studies in PCB developmental neurotoxicity. These are metabolized cytochrome P450 (P450) enzymes to potentially neurotoxic hydroxylated metabolites (OH-PCBs). The present study explores the enantioselective disposition toxicity of 2 environmentally relevant, their OH-PCB lactating mice offspring following dietary exposure dam. Female C57BL/6N (8-weeks old) were fed daily, beginning 2 weeks prior conception continuing throughout gestation lactation, with 3.1 µmol/kg bw/d racemic 2,2',3,5',6-pentachlorobiphenyl (PCB 95) or 2,2',3,3',6,6'-hexachlorobiphenyl 136) peanut butter; controls received vehicle (peanut oil) butter. 95 levels higher than 136 both dams pups, consistent more rapid metabolism compared 95. In pups dams, enriched for enantiomer eluting second on gas chromatography columns. profiles complex varied according congener, tissue age. Developmental versus differentially affected expression as well neural plasticity (arc ppp1r9b) thyroid hormone-responsive genes (nrgn mbp). results suggest that PCBs OH-PCBs may influence outcomes exposures, a hypothesis warrants further investigation.