α-Aminoacid-N-Carboxy-Anhydrides and Related Heterocycles: Syntheses, Properties, Peptide Synthesis, Polymerization

摘要: 1. Synthesis and Characterization of NCAs.- 1.1 Syntheses ?-Amino Acid 1.2 ss- 1.3 Thio Analogs ?- ss-Amino 1.4 Purification Titration 1.5 IR Spectroscopy.- 1.6 NMR 1.7 Tables References.- 2. Oligomerization Polymerization NCAs: Chemical Aspects..- 2.1 Background.- 2.2 Stoichiometric Reactions 2.2.1 with Protic Nucleophiles.- 2.2.2 Various Reactions.- 2.3 Stepwise Peptide Syntheses.- 2.3.1 With N-Unsubstituted 2.3.2 TV-Substituted 2.4 2.4.1 Primary Amines.- 2.4.2 Secondary 2.4.3 The Carbamate Mechanism.- 2.5 Tertiary 2.5.1 Trialkylamines.- 2.5.2 Pyridines.- 2.6 Metal Salts Organometallic Compounds.- 2.6.1 Anions.- 2.6.2 Initiators.- 2.7 Thermal Polymerizations.- 2.8 NCA 2.8.1 2.8.2 3. Physical Aspects.- 3.1 Determination Molecular Weights.- 3.1.1 Endgroup Analyses.- 3.1.2 Methods.- 3.2 Weight Distributions Polydispersity.- 3.3 Chain-Effect Polymerization.- 3.3.1 Chain Effect Polysarcosine.- 3.3.2 Helical Growth.- 3.3.3 Template 3.4 Structure Solid Polypeptides.- 3.4.1 Definitions 3.4.2 Crystal References.