Blockade of 5-HT2A receptors inhibits emotional hyperthermia in mice.

摘要: This study determined whether blockade of 5-hydroxytryptamine 2A (5-HT2A) receptors attenuated hyperthermia and tachycardia responses to psychological stress in mice. For this purpose, male mice (C57BL/6N) were pre-instrumented with a telemetric probe measure core body temperature heart rate prior experimentation. Vehicle or 5-HT2A antagonist, eplivanserin hemifumarate (SR-46349B) ((1Z,2E)-1-(2-fluorophenyl)-3-(4-hydroxyphenyl)-2-propen-1-one O-[2-(dimethylamino) ethyl] oxime hemifumarate) (0.5, 1.0, 5.0 mg/kg), was injected intraperitoneally. To elicit stress, an intruder mouse confined small cage introduced into the resident mouse’s 30 min after administration injection. The application increased by ~ 1.0 °C by ~ 150 bpm vehicle group. In contrast, SR-46349B shown reduce stress-induced increase dose-dependent manner (P < 0.05). However, treatment groups had no influence on intruder-elicited rate. study, therefore, suggests that play significant role mediating hyperthermia, but not tachycardia, during stress.