Evaluating mitochondrial DNA in cancer occurrence and development
作者： Lijun Shen , Hezhi Fang , Tao Chen , Jing He , Mei Zhang
DOI: 10.1111/J.1749-6632.2010.05635.X
关键词:
摘要: Abnormal mitochondria have long been hypothesized to be involved in tumorigenesis. Mitochondrial DNA (mtDNA) mutations found various cancer cells, yet their role tumorigenesis remains largely unknown. Our long-term goal is understand the of mtDNA polymorphism and We focused on haplogroup; a 4,977 bp common deletion; main control region or displacement loop; heteroplasmy occurrence development. results indicate that qualitative quantitative changes play an important
harvard.edu
utsystem.edu参考文章(39)
Giuseppe Attardi, Animal Mitochondrial DNA: An Extreme Example of Genetic Economy International Review of Cytology. ,vol. 93, pp. 93- 145 ,(1985) , 10.1016/S0074-7696(08)61373-X
Peter L. Pedersen, Tumor mitochondria and the bioenergetics of cancer cells. Progress in Experimental Tumor Research. ,vol. 22, pp. 190- 274 ,(1978) , 10.1159/000401202
Kornelia Polyak, Yunbo Li, Hong Zhu, Christoph Lengauer, James K.V. Willson, Sanford D. Markowitz, Michael A. Trush, Kenneth W. Kinzler, Bert Vogelstein, Somatic mutations of the mitochondrial genome in human colorectal tumours Nature Genetics. ,vol. 20, pp. 291- 293 ,(1998) , 10.1038/3108
John S. Penta, F.M. Johnson, Joseph T. Wachsman, William C. Copeland, Mitochondrial DNA in human malignancy. Mutation Research-reviews in Mutation Research. ,vol. 488, pp. 119- 133 ,(2001) , 10.1016/S1383-5742(01)00053-9
Yewei Ma, Ren-Kui Bai, Robert Trieu, Lee-Jun C. Wong, Mitochondrial dysfunction in human breast cancer cells and their transmitochondrial cybrids. Biochimica et Biophysica Acta. ,vol. 1797, pp. 29- 37 ,(2010) , 10.1016/J.BBABIO.2009.07.008
Hsin-Chen Lee, Yau-Huei Wei, Mitochondrial DNA instability and metabolic shift in human cancers. International Journal of Molecular Sciences. ,vol. 10, pp. 674- 701 ,(2009) , 10.3390/IJMS10020674
Zhinan Ding, Jingzhang Ji, Guorong Chen, Hezhi Fang, Shihui Yan, Lijun Shen, Jia Wei, Kaiyan Yang, Jianxin Lu, Yidong Bai, None, Analysis of mitochondrial DNA mutations in D-loop region in thyroid lesions. Biochimica et Biophysica Acta. ,vol. 1800, pp. 271- 274 ,(2010) , 10.1016/J.BBAGEN.2009.05.009
Jianxin Lu, Lokendra Kumar Sharma, Yidong Bai, Implications of mitochondrial DNA mutations and mitochondrial dysfunction in tumorigenesis. Cell Research. ,vol. 19, pp. 802- 815 ,(2009) , 10.1038/CR.2009.69
Gordon F. Schwartz, Kevin S. Hughes, Henry T. Lynch, Carol J. Fabian, Ian S. Fentiman, Mark E. Robson, Susan M. Domchek, Lynn C. Hartmann, Roland Holland, David J. Winchester, , Proceedings of the International Consensus Conference on Breast Cancer Risk, Genetics, & Risk Management, April, 2007 Cancer. ,vol. 113, pp. 2627- 2637 ,(2008) , 10.1002/CNCR.23903
D. A. Clayton, J. Vinograd, COMPLEX MITOCHONDRIAL DNA IN LEUKEMIC AND NORMAL HUMAN MYELOID CELLS Proceedings of the National Academy of Sciences of the United States of America. ,vol. 62, pp. 1077- 1084 ,(1969) , 10.1073/PNAS.62.4.1077