Dihydrotestosterone blocks fetal lung fibroblast-pneumonocyte factor at a pretranslational level.

摘要: Fibroblast pneumonocyte factor (FPF) synthesis by fetal rat lung fibroblasts is augmented during gestation in the presence of cortisol. The control and cortisol-augmented levels FPF production, as determined ability to stimulate saturated phosphotidylcholine epithelial Type II cells, delayed development derived from male fetuses compared those female fetuses. mechanism which this delay occurs has been addressed. Pregnant rats treated vivo with dihydrotestosterone (DHT) showed decreased activity or cortisol-treated 20-day-old In vitro translated proteins size-fractionated RNA 19-day-old that were pretreated DHT nontreated samples. This was present even if DHT-pretreated cells stimulated cortisol prior preparation. Using a mouse model testicular feminization contains no receptors for androgens change when DHT. These data taken together suggest production male-derived physiologic process requires androgen receptors, inhibit appears affect events occurring mainly at pretranslational level.