NR4A Orphan Receptors as Drug Targets
作者： Stephen Safe , Syng-Ook Lee , Cong Meng , Beiyan Zhou
DOI: 10.1007/978-1-4939-1393-0_26
关键词:
摘要: The orphan receptor NR4Al (Nur77, TR3, NGFI-B) is overexpressed in many different cancer cell lines and tumors, and, leukemia cells, also more highly expressed than B- or T-cell. In contrast, we observed the opposite pattern of NR4A2 (Nurrl) expression these same cells. primarily oncogenic a target for inhibitors inactivators treatment Jurkat cells with an inactivator-induced apoptosis inhibited growth. vitro characterization as pro-oncogenic contrast to tumor suppressor-like activity transgenic mouse models, differences are currently being investigated.
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