TopBP1 assembles nuclear condensates to switch on ATR signaling.

作者: Camilla Frattini , Alexy Promonet , Emile Alghoul , Sophie Vidal-Eychenie , Marie Lamarque

DOI: 10.1016/J.MOLCEL.2020.12.049

关键词:

摘要: … by fluorescence … phosphorylation events occurring within TopBP1 condensates (Figure S6B). In contrast, we did not isolate biotinylated phospho ATR, phospho TopBP1, and phospho-…

参考文章(88)
R S Maser, K J Monsen, B E Nelms, J H Petrini, hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks. Molecular and Cellular Biology. ,vol. 17, pp. 6087- 6096 ,(1997) , 10.1128/MCB.17.10.6087
Tomas Lindahl, Instability and decay of the primary structure of DNA Nature. ,vol. 362, pp. 709- 715 ,(1993) , 10.1038/362709A0
A. E. Burrows, S. J. Elledge, How ATR turns on: TopBP1 goes on ATRIP with ATR Genes & Development. ,vol. 22, pp. 1416- 1421 ,(2008) , 10.1101/GAD.1685108
Ian A. Prior, Cornelia Muncke, Robert G. Parton, John F. Hancock, Direct visualization of ras proteins in spatially distinct cell surface microdomains Journal of Cell Biology. ,vol. 160, pp. 165- 170 ,(2003) , 10.1083/JCB.200209091
Christopher Van, Shan Yan, W. Matthew Michael, Shou Waga, Karlene A. Cimprich, Continued primer synthesis at stalled replication forks contributes to checkpoint activation. Journal of Cell Biology. ,vol. 189, pp. 233- 246 ,(2010) , 10.1083/JCB.200909105
Stephen P. Jackson, Jiri Bartek, The DNA-damage response in human biology and disease Nature. ,vol. 461, pp. 1071- 1078 ,(2009) , 10.1038/NATURE08467
Shizhou Liu, Simon Bekker-Jensen, Niels Mailand, Claudia Lukas, Jiri Bartek, Jiri Lukas, Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation. Molecular and Cellular Biology. ,vol. 26, pp. 6056- 6064 ,(2006) , 10.1128/MCB.00492-06
A. Marechal, L. Zou, DNA damage sensing by the ATM and ATR kinases. Cold Spring Harbor Perspectives in Biology. ,vol. 5, ,(2013) , 10.1101/CSHPERSPECT.A012716
Minna Mäkiniemi, Tomi Hillukkala, Jussi Tuusa, Kaarina Reini, Markku Vaara, Deqi Huang, Helmut Pospiech, Inkeri Majuri, Thomas Westerling, Tomi P. Mäkelä, Juhani E. Syväoja, BRCT domain-containing protein TopBP1 functions in DNA replication and damage response. Journal of Biological Chemistry. ,vol. 276, pp. 30399- 30406 ,(2001) , 10.1074/JBC.M102245200