PDZ Domains as Drug Targets.
作者： Nikolaj R Christensen , Jelena Čalyševa , Eduardo FA Fernandes , Susanne Lüchow , Louise S Clemmensen
关键词:
摘要: Protein-protein interactions within protein networks shape the human interactome, which often is promoted by specialized interaction modules, such as postsynaptic density-95 (PSD-95), discs-large, zona occludens 1 (ZO-1) (PDZ) domains. PDZ domains play a role in several cellular functions, from cell-cell communication and polarization, to regulation of transport metabolism. domain proteins are also crucial formation stability complexes, establishing an important bridge between extracellular stimuli detected transmembrane receptors intracellular responses. have been suggested promising drug targets diseases, ranging neurological oncological disorders viral infections. In this review, authors describe structural genetic aspects PDZ-containing discuss current status development small-molecule peptide modulators An overview potential new therapeutic interventions PDZ-mediated provided.
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