Sildenafil in pediatric pulmonary arterial hypertension
作者： AK Dhariwal , SB Bavdekar
关键词:
摘要: Pulmonary arterial hypertension (PAH) is a life-threatening disease of varied etiologies. Although PAH has no curative treatment, greater understanding pathophysiology, technological advances resulting in early diagnosis, and the availability several newer drugs have improved outlook for patients with PAH. Sildenafil one therapeutic agents used extensively treatment children, as an off-label drug. In 2012, United States Food Drug Administration (USFDA) issued warning regarding use high-dose sildenafil children This led to peculiar situation where there paucity approved therapies management most drug being discouraged by regulator. article provides review children.
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