Specific regulation of N-CAM/D2-CAM cell adhesion molecule during skeletal muscle development.

摘要: Abstract The expression of the N-CAM/D2-CAM cell adhesion molecule was studied in skeletal muscle. In cultures derived from adult human muscle found at surface myoblasts and myotubes but not fibroblasts, showing that is a specific gene product Western blots showed anti antibody reacted with single protein band 180 000 daltons these differed mobility broad 150 000-200 brain. also expressed by certain stages development. Human foetal 10 20 weeks gestation around developing myofibres while both fast slow fibres did express N-CAM/D2-CAM, suggesting down regulated during myofibre maturation. This further rat where on day 1 neonate, had disappeared 9. is, however, re-expressed disease there regeneration such as polymyositis, here associated classic regenerating myofibres. temporally only times synapse formation consistent idea it may be involved early nerve-muscle interactions.