Comparison of Lormetazepam Solution and Capsules in Healthy Volunteers
作者： P. Guerra , A. Soto , A.J. Carcas , A. Sancho , A. Cassinello
DOI: 10.2165/00044011-200222120-00006
关键词:
摘要: Objective The aim of this study was to demonstrate a faster absorption and disposition rate for solution formulation lormetazepam, comparing the bio-availability two different oral formulations (tablets solution), in healthy volunteers.
springer.com
sci-hub.se 参考文章(17)
D. K. Luscombe, Lormetazepam — Plasma Concentrations in Volunteers Following Sublingual and Oral Dosing Sleep, Benzodiazepines and Performance. ,vol. 1, pp. 98- 104 ,(1984) , 10.1007/978-3-642-69659-6_9
D Hauschke, V W Steinijans, E Diletti, A distribution-free procedure for the statistical analysis of bioequivalence studies. International journal of clinical pharmacology, therapy, and toxicology. ,vol. 28, pp. 72- 78 ,(1990)
Herman P. Wijnand, On the assessment of bioequivalence in a two-period cross-over design Computer Methods and Programs in Biomedicine. ,vol. 37, pp. 151- 157 ,(1992) , 10.1016/0169-2607(92)90097-Q
C. Gudex, Adverse effects of benzodiazepines. Social Science & Medicine. ,vol. 33, pp. 587- 596 ,(1991) , 10.1016/0277-9536(91)90216-Y
K Adam, I Oswald, Effects of lormetazepam and of flurazepam on sleep. British Journal of Clinical Pharmacology. ,vol. 17, pp. 531- 538 ,(1984) , 10.1111/J.1365-2125.1984.TB02386.X
David J. Greenblatt, Lawrence G. Miller, Richard I. Shader, Neurochemical and pharmacokinetic correlates of the clinical action of benzodiazepine hypnotic drugs The American Journal of Medicine. ,vol. 88, pp. S18- S24 ,(1990) , 10.1016/0002-9343(90)90281-H
L. Zecca, P. Ferrario, F. Fraschini, F. Zambotti, N. Zonta, R. Pirola, Determination of lormetazepam in plasma by gas chromatography and electron-capture detection Journal of Chromatography B: Biomedical Sciences and Applications. ,vol. 377, pp. 368- 372 ,(1986) , 10.1016/S0378-4347(00)80795-1
David Wheatley, Prescribing short-acting hypnosedatives. Current recommendations from a safety perspective. Drug Safety. ,vol. 7, pp. 106- 115 ,(1992) , 10.2165/00002018-199207020-00003
Pierre Gaudreault, Joanne Guay, Robert L. Thivierge, Isabelle Verdy, Benzodiazepine poisoning. Clinical and pharmacological considerations and treatment. Drug Safety. ,vol. 6, pp. 247- 265 ,(1991) , 10.2165/00002018-199106040-00003
V. W. Steinijans, E. Diletti, Generalization of distribution--free confidence intervals for bioavailability ratios. European Journal of Clinical Pharmacology. ,vol. 28, pp. 85- 88 ,(1985) , 10.1007/BF00635713