Meeting the physical activity guidelines and survival after breast cancer: findings from the after breast cancer pooling project

摘要: The 2008 Physical Activity (PA) Guidelines recommend engaging in at least 2.5 h (10 MET-hours/week) of moderate intensity PA per week (defined as 4 METs) to reduce risk morbidity and mortality. This analysis was conducted investigate whether this recommendation can be extended breast cancer survivors. Data from four studies survivors measuring recreational semi-quantitative questionnaires a median 23 months post-diagnosis (interquartile range 18-32 months) were pooled the After Breast Cancer Pooling Project (n = 13,302). Delayed entry Cox proportional hazards models applied data with adjustment for age, body mass index, race/ethnicity, menopausal status, TNM stage, treatment, smoking history. Engaging 10 MET-hours/week associated 27% reduction all-cause mortality 1,468 events, Hazard Ratio (HR) 0.73, 95% CI, 0.66-0.82) 25% 971 HR 0.75, CI 0.65-0.85) compared women who did not meet (<10 MET-hours/week). Risk recurrence 1,421 events) meeting (HR 0.96, 0.86-1.06). These suggest that adhering guidelines may an important intervention target reducing among