Cerebral malaria and developmental biology: making parasites grow-up.
作者： R.D. Pearson
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摘要: Erythrocytes infected with the protozoan parasite Plasmodium falciparum, in final stages of asexual development, sequester and adhere to lining capillaries brain; killing 1-3 million (mostly children under age 5) each year. I will argue here that rapidly evolving tools developmental biology be employed find a way inducing gametocytogenesis, thereby making 'grow-up' prematurely, large numbers alleviating severe symptoms brain.
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sci-hub.se 参考文章(12)
R.E. Sinden, G.A. Butcher, O. Billker, S.L. Fleck, Regulation of Infectivity of Plasmodium to the Mosquito Vector Advances in Parasitology Volume 38. ,vol. 38, pp. 53- 117 ,(1996) , 10.1016/S0065-308X(08)60033-0
F E McKenzie, W H Bossert, A target for intervention in Plasmodium falciparum infections American Journal of Tropical Medicine and Hygiene. ,vol. 58, pp. 763- 767 ,(1998) , 10.4269/AJTMH.1998.58.763
Karen P Day, Rhian E Hayward, Deborah Smith, Janetta G Culvenor, CD36-dependent adhesion and knob expression of the transmission stages of Plasmodium falciparum is stage-specific Molecular and Biochemical Parasitology. ,vol. 93, pp. 167- 177 ,(1998) , 10.1016/S0166-6851(98)00040-1
Roy Douglas Pearson, Cerebral malaria and the induction of gametocytogenesis. Parasitology Today. ,vol. 14, pp. 378- ,(1998) , 10.1016/S0169-4758(98)01306-4
NJ White, Not much progress in treatment of cerebral malaria The Lancet. ,vol. 352, pp. 594- 595 ,(1998) , 10.1016/S0140-6736(05)79572-6
L.H Taylor, A.F Read, Why so few transmission stages? Reproductive restraint by malaria parasites Parasitology Today. ,vol. 13, pp. 135- 140 ,(1997) , 10.1016/S0169-4758(97)89810-9
Walther H. Wernsdorfer, McGregor, Ian, Sir, Malaria: Principles and Practice of Malariology ,(1989)
W.G. Maccallum, ON THE FLAGELLATED FORM OF THE MALARIAL PARASITE. The Lancet. ,vol. 150, pp. 1240- 1241 ,(1897) , 10.1016/S0140-6736(00)46556-6
J L Williams, Stimulation of Plasmodium falciparum gametocytogenesis by conditioned medium from parasite cultures. American Journal of Tropical Medicine and Hygiene. ,vol. 60, pp. 7- 13 ,(1999) , 10.4269/AJTMH.1999.60.7
A. BUCKLING, L. C. RANFORD-CARTWRIGHT, A. MILES, A. F. READ, Chloroquine increases Plasmodium falciparum gametocytogenesis in vitro. Parasitology. ,vol. 118, pp. 339- 346 ,(1999) , 10.1017/S0031182099003960