Action of anionic and cationic nerve-blocking agents: experiment and interpretation.
作者： M. P. Blaustein , D. E. Goldman
DOI: 10.1126/SCIENCE.153.3734.429
关键词:
摘要: Barbiturates and anesthetics similar to procaine bind phospholipids in vitro. The former increase the binding of calciumn phospholipids; latter decrease it. data can be correlated with effects these drugs Otl peripheral nerve. nonpolar portion narcotic agents may lie between lipid chains membrane, charged region close approximation polar heads phospholipids.
sciencemag.org参考文章(25)
Clay M. Armstrong, Leonard Binstock, THE EFFECTS OF SEVERAL ALCOHOLS ON THE PROPERTIES OF THE SQUID GIANT AXON. The Journal of General Physiology. ,vol. 48, pp. 265- 277 ,(1964) , 10.1085/JGP.48.2.265
J. A. Clements, K. M. Wilson, THE AFFINITY OF NARCOTIC AGENTS FOR INTERFACIAL FILMS Proceedings of the National Academy of Sciences. ,vol. 48, pp. 1008- 1014 ,(1962) , 10.1073/PNAS.48.6.1008
A. P. TRUANT, B. TAKMAN, Differential physical-chemical and neuropharmacologic properties of local anesthetic agents. Anesthesia & Analgesia. ,vol. 38, pp. 478- 484 ,(1959) , 10.1213/00000539-195911000-00018
L. Pauling, A Molecular Theory of General Anesthesia: Anesthesia is attributed to the formation in the brain of minute hydrate crystals of the clathrate type Science. ,vol. 134, pp. 15- 21 ,(1961) , 10.1126/SCIENCE.134.3471.15
S. L. Miller, A theory of gaseous anesthetics. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 47, pp. 1515- 1524 ,(1961) , 10.1073/PNAS.47.9.1515
J. del CASTILLO-NICOLAU, H. J. HUFSCHMIDT, Reversible Poisoning of Nerve Fibres by Heavy-Metal Ions Nature. ,vol. 167, pp. 146- 147 ,(1951) , 10.1038/167146B0
S. W. Benson, J. W. King, Electrostatic Aspects of Physical Adsorption: Implications for Molecular Sieves and Gaseous Anesthesia Science. ,vol. 150, pp. 1710- 1713 ,(1965) , 10.1126/SCIENCE.150.3704.1710
Jens Chr. Skou, Relation between the ability of various compounds to block nervous conduction and their penetration into a monomolecular layer of nerve-tissue lipoids Biochimica et Biophysica Acta. ,vol. 30, pp. 625- 629 ,(1958) , 10.1016/0006-3002(58)90110-0
John W. Moore, Werner Ulbricht, Mitsuru Takata, EFFECT OF ETHANOL ON THE SODIUM AND POTASSIUM CONDUCTANCES OF THE SQUID AXON MEMBRANE. The Journal of General Physiology. ,vol. 48, pp. 279- 295 ,(1964) , 10.1085/JGP.48.2.279
D. Agin, L. Hersh, D. Holtzman, The action of anesthetics on excitable membranes: a quantum-chemical analysis. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 53, pp. 952- 958 ,(1965) , 10.1073/PNAS.53.5.952