Synthesis and Characterization of Potentially Antimicrobial Complexes of Zn(II) and Cu(II) with Chlorhexidine as Ligand

摘要: Chlorhexidine, 1,1'-hexamethylene-bis-[5-(p-chlorophenyl)-biguanide] is a clinically used antiseptic agent with broad activity spectrum, effective against either Gram positive bacteria such as Mutans streptococcus or negative Pseudomonas aeruginosa. It has eliminating effects on some mycobacteria. In order to prevent the loss of biological caused by poor solubility chlorhexidine and limit side when antiseptic, we synthesised Zn(II)- Cu(II)- complexes chlorhexidine, L1, well diacetate, L2, in 1:1 1:2 M:L molar ratios. Based elemental analysis data, IR UV-Vis spectroscopy, ESI-MS spectrometry proposed appropriate molecular formulae complexes.